Mesenchymal Stem Cells are paramount candidates for Orthopedic Repair, offering a biological solution for challenging conditions like non-union fractures and degenerative joint diseases such as osteoarthritis. In cartilage repair, MSCs are injected directly into the joint or seeded onto biodegradable scaffolds to regenerate damaged tissue. Their primary therapeutic contribution stems from both their ability to differentiate into chondrocytes (cartilage cells) and their strong paracrine signaling.

The secreted trophic factors and anti-inflammatory molecules create a favorable microenvironment, stimulating resident host cells to participate in the healing process and reducing inflammation that would otherwise destroy new tissue. For bone regeneration, particularly large bone defects, MSCs are often combined with a bioscaffold and osteoinductive factors to promote osteogenesis and provide structural support. This ability to integrate cellular components with bio-engineered materials places MSCs at the forefront of orthobiologics innovation.

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